Mechanism and modification of rejection of heterografts between divergent species.

نویسندگان

  • G R Giles
  • H J Boehmig
  • J Lilly
  • H Amemiya
  • H Takagi
  • A J Coburg
  • W E Hathaway
  • C B Wilson
  • F J Dixon
  • T E Starzl
چکیده

THIS STUDY WAS UNDERTAKEN with several specific objectives: to evaluate the role of preformed heterospecific antibodies in causing hyperacute rejection of whole organs transplanted from dogs to pigs or pigs to dogs; to see how much this abrupt rejection could be mitigated by the antibody depletion that occurs with the use of successive organs; to establish the contribution of coagulation changes to the pathogenesis of this kind of hyperacute rejection; and to determine if there were similarities between abrupt heterograft rejection and hyperacute rejection of homografts in presensitized recipients.

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عنوان ژورنال:
  • Transplantation proceedings

دوره 2 4  شماره 

صفحات  -

تاریخ انتشار 1970